A Single Initiating Cause of Hypertension; Potential for Primary Prevention
نویسنده
چکیده
Peptide growth factors (PGF’s) are potent regulators of cell growth from unicellular to complex multicellular organisms. Through a combination of autocrine, paracrine, and endocrine modes of action, PGF’s control the activity of all other growth modulators including classical hormones, such as the Renin-Angiotensin-Aldosterone (RAA) system, which they predate on the evolutionary scale [3]. Epidermal growth factor (EGF) and its epidermal growth factor receptor (EGFR), when present, dominate this control through a process of extensive cross talk and transactivation.
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